Fig. 1
From: Deregulated expression of cryptochrome genes in human colorectal cancer
Expression of CRY1 and CRY2 mRNA and protein levels in colorectal cancer tissue and survival rates. a CRY1 and CRY2 mRNA levels analysed by qRT-PCR in colorectal cancer tissue and compared with matched normal tissue, with GAPDH expression used as the calibrator. A box and whisker plot is shown representing the interquartile range (IQR) with median, 25th and 75th percentile, minimum and maximum values, as well as outliers indicated by dots. b x-y plot showing regression lines with 95 % confidence limits between CRY1 and CRY2 mRNA expression levels in tumour tissues of CRC patients (n = 50, r = 0.607, p < 0.0001) c) CRY1 and CRY2 protein level evaluated by western blotting in a panel of matched specimens of tumour tissue and non-tumorous tissue. A box and whisker plot is shown representing the interquartile range (IQR) with median, 25th and 75th percentile, minimum and maximum values; d) Cumulative survival of CRC patients according to CRY1 (left) and CRY2 (right) expression levels. A significant difference was found in cumulative survival rates of CRC patients splitted at the median value according to CRY1 expression (p = 0.042) and CRY2 expression (p = 0.043). Patients with high expression levels showed significantly poorer survival rates