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Table 2 Association of Cry1 and Cry2 mRNA levels with clinical and pathological features of colorectal cancer patients

From: Deregulated expression of cryptochrome genes in human colorectal cancer

    Cry1   Cry2  
   n = 50 Median Q1 Q3 P value Median Q1 Q3 P value
Age <62 16 1.067 0.727 1.315 0.018 0.661 0.318 0.920 0.408
62-74 19 0.552 0.291 1.078 0.423 0.248 0.770
>74 15 0.715 0.329 0.943 0.434 0.211 0.742
Gender Male 34 0.879 0.427 1.398 0.003 0.432 0.236 0.801 0.677
Female 16 0.686 0.442 0.819 0.551 0.297 0.673
Tumor Location Proximal colona 17 0.722 0.323 1.078 0.008 0.434 0.254 0.742 0.007
Transverse colon 6 0.546 0.389 0.649 0.232 0.127 0.309
Distal colonb 27 0.935 0.560 1.398 0.644 0.280 0.898
Grading G1/G2 45 0.726 0.427 1.174 0.778 0.477 0.248 0.801 0.925
G3/G4 5 0.841 0.556 1.270 0.552 0.309 0.675
Modified Dukes Staging System A 4 0.612 0.419 0.912 0.929 0.326 0.203 0.831 0.397
B 20 0.770 0.562 1.006 0.429 0.202 0.734
C 24 0.713 0.375 1.354 0.572 0.275 0.891
D 2 1.145 0.389 1.901 1.566 0.309 2.823
Histologic Type Non mucinous adenocarcinoma 45 0.318 0.291 0.552 0.311 0.592 0.270 0.607 0.083
Mucinous adenocarcinoma 5 0.798 0.509 1.236 0.477 0.254 0.770
MSI frequency missing 12 - - - 0.659 - - - 0.555
High 9 0,560 0,389 1,174 0,550 0,350 0,717
Low 10 0,770 0,583 1,110 0,403 0,248 0,675
Stable 19 0,628 0,318 1,078 0,592 0,270 1,043
Tumor extent 2 4 0.612 0.419 0.912 0.582 0.326 0.203 0.831 0.625
3 43 0.798 0.495 1.270 0.550 0.267 0.801
4 3 0.389 0.208 1.310 0.309 0.127 0.717
Lymph node involvement N0 24 0.727 0.502 1.006 0.205 0.438 0.230 0.785 0.482
N1 14 0.569 0.318 1.270 0.419 0.269 0.715
N2 12 1.059 0.556 2.020 0.571 0.329 1.135
TNM Stage I-II 27 0.628 0.323 1.398 0.899 0.552 0.270 1.039 0.247
III-IV 23 0.727 0.509 1.078 0.434 0.211 0.770
Vascular Invasion Not 27 0.727 0.509 1.110 0.620 0.552 0.267 0.801 0.621
Yes 23 0.726 0.389 1.580 0.350 0.248 0.717
  1. aCaecum and ascending colon bDescending colon, sigmoid colon and rectum