Table 2 Association of Cry1 and Cry2 mRNA levels with clinical and pathological features of colorectal cancer patients

Age

<62

16

1.067

0.727

1.315

0.018

0.661

0.318

0.920

0.408

62-74

19

0.552

0.291

1.078

0.423

0.248

0.770

>74

15

0.715

0.329

0.943

0.434

0.211

0.742

Gender

Male

34

0.879

0.427

1.398

0.003

0.432

0.236

0.801

0.677

Female

16

0.686

0.442

0.819

0.551

0.297

0.673

Tumor Location

Proximal colon^a

17

0.722

0.323

1.078

0.008

0.434

0.254

0.742

0.007

Transverse colon

6

0.546

0.389

0.649

0.232

0.127

0.309

Distal colon^b

27

0.935

0.560

1.398

0.644

0.280

0.898

Grading

G1/G2

45

0.726

0.427

1.174

0.778

0.477

0.248

0.801

0.925

G3/G4

5

0.841

0.556

1.270

0.552

0.309

0.675

Modified Dukes Staging System

A

4

0.612

0.419

0.912

0.929

0.326

0.203

0.831

0.397

B

20

0.770

0.562

1.006

0.429

0.202

0.734

C

24

0.713

0.375

1.354

0.572

0.275

0.891

D

2

1.145

0.389

1.901

1.566

0.309

2.823

Histologic Type

Non mucinous adenocarcinoma

45

0.318

0.291

0.552

0.311

0.592

0.270

0.607

0.083

Mucinous adenocarcinoma

5

0.798

0.509

1.236

0.477

0.254

0.770

MSI frequency

missing

12

-

-

-

0.659

-

-

-

0.555

High

9

0,560

0,389

1,174

0,550

0,350

0,717

Low

10

0,770

0,583

1,110

0,403

0,248

0,675

Stable

19

0,628

0,318

1,078

0,592

0,270

1,043

Tumor extent

2

4

0.612

0.419

0.912

0.582

0.326

0.203

0.831

0.625

3

43

0.798

0.495

1.270

0.550

0.267

0.801

4

3

0.389

0.208

1.310

0.309

0.127

0.717

Lymph node involvement

N0

24

0.727

0.502

1.006

0.205

0.438

0.230

0.785

0.482

N1

14

0.569

0.318

1.270

0.419

0.269

0.715

N2

12

1.059

0.556

2.020

0.571

0.329

1.135

TNM Stage

I-II

27

0.628

0.323

1.398

0.899

0.552

0.270

1.039

0.247

III-IV

23

0.727

0.509

1.078

0.434

0.211

0.770

Vascular Invasion

Not

27

0.727

0.509

1.110

0.620

0.552

0.267

0.801

0.621

Yes

23

0.726

0.389

1.580

0.350

0.248

0.717