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Fig. 5 | Molecular Cancer

Fig. 5

From: miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis

Fig. 5

NFKB1 re-expression partly abrogated the inhibitory effect of miR-508-3p in GC. a Expression of miR-508-3p in paired primary GC samples (n = 28; P = 0.155). b miR-508-3p expression was negatively correlated with NFKB1 protein expression in primary gastric tumors (P = 0.033). c The Western blot analysis of NFKB1 in the rescue experiments. d NFKB1 re-expression promoted cell proliferation compared with miR-508-3p alone in MKN28 and SGC-7901 cells (*, P < 0.05; **, P < 0.001). The SDs were get by the 575 nm absorbance readings in 4 wells of each item. e NFKB1 re-expression counteracted proliferation-inhibition effect of miR-508-3p revealed by monolayer colony formation assays revealed (*, P < 0.05). The representative colony formation figures were shown in the bottom

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