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Fig. 1 | Molecular Cancer

Fig. 1

From: Aurora kinase targeting in lung cancer reduces KRAS-induced transformation

Fig. 1

KRAS induces expression of AURKA and AURKB in lung cells. a Protein lysates of SALEB and SAKRAS cells were submitted to western blotting with the indicated antibodies. b H1703-TrexB and H1703-G12V lung cancer cells were treated with 2 μg/mL doxycycline (DOX) for 24 h where indicated to induce KRAS expression. Subsequently, protein lysates were prepared and submitted to western blotting with the indicated antibodies. TUBA) anti-α-tubulin. c A549 and H358 stable cells with inducible expression of 2 different shRNAs targeting KRAS (shKR#1 and shKR#2) or a non-targeting shRNA (shCtrl) were treated with 2 μg/mL doxycycline (DOX) for 5 days to induce shRNA expression where indicated. Protein lysates were prepared and submitted to western blotting with the indicated antibodies

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