Fig. 5
From: MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α
miR-505 directly targets TGFA. The predicted seed region in the 3′ UTR of TGF-α (a); Luciferase activity is unchanged when using a scrambled miRNA sequence or miR-505 with the mutant 3′-UTR of TGF-α. However, when the wild-type 3′-UTR of TGF-α is used, the promoter activity is significantly reduced by miR-505 (b). Results are representative of three separate experiments; data are expressed as the mean ± standard deviation, *P < 0.05