Fig. 7From: Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion, thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?Changes of adhesion proteins co-cultured with HUVEC and ovarian cancer cells. Co-culture model of human ovarian cancer cells with HUVEC without (dark grey bar) and with (light grey bar) VEGF-inhibition via Flt1-Fc. Changes in claudin 5 and VE-cadherin were measured using Real-time PCR. VEGF inhibition revealed a significant increase of claudin 5 and VE-cadherin in comparison to the co-culture without inhibition (both p < 0.05) (a and b)Back to article page