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Fig. 7 | Molecular Cancer

Fig. 7

From: Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion, thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?

Fig. 7

Changes of adhesion proteins co-cultured with HUVEC and ovarian cancer cells. Co-culture model of human ovarian cancer cells with HUVEC without (dark grey bar) and with (light grey bar) VEGF-inhibition via Flt1-Fc. Changes in claudin 5 and VE-cadherin were measured using Real-time PCR. VEGF inhibition revealed a significant increase of claudin 5 and VE-cadherin in comparison to the co-culture without inhibition (both p < 0.05) (a and b)

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