Table 1 Relationship between CTSB expression and clinicopathologic features of HCC patients
From: Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients
Clinicopathologic parameters | n | CTSB expression | P value | |
|---|---|---|---|---|
Positive (%) | Negative (%) | |||
All cases | 168 | 90 (53.5 %) | 78 (46.5 %) | |
Gender | 0.562 | |||
Male | 110 | 57 (51.8 %) | 53 (48.2 %) | |
Female | 58 | 32 (55.2 %) | 26 (44.8 %) | |
Age (years) | 0.310 | |||
<50 | 123 | 61 (49.6 %) | 62 (50.4 %) | |
≥50 | 45 | 26 (57.8 %) | 19 (42.2 %) | |
Tumor size (cm)a | 0.622 | |||
<5 | 131 | 71 (54.2 %) | 60 (45.8 %) | |
≥5 | 37 | 19 (51.4 %) | 18 (48.6 %) | |
Serum HBsAg | 0.125 | |||
Positive | 147 | 82 (55.8 %) | 65 (44.2 %) | |
Negative | 21 | 10 (47.6 %) | 11 (52.4 %) | |
Serum AFP (ng/ml) | 0.814 | |||
<25 | 50 | 25 (50.0 %) | 25 (50.0 %) | |
≥25 | 118 | 60 (50.8 %) | 58 (49.2 %) | |
Cirrhosis | 0.078 | |||
Presence | 145 | 78 (53.8 %) | 67 (46.2 %) | |
Absence | 23 | 10 (43.5 %) | 13 (56.5 %) | |
UICC stage | 0.004 | |||
I + II | 100 | 32 (32.0 %) | 68 (68.0 %) | |
III + IV | 68 | 48 (70.6 %) | 20 (29.4 %) | |
Metastasis/Recurrence | 0.000 | |||
Yes | 133 | 88 (66.2 %) | 45 (33.8 %) | |
No | 35 | 12 (34.3 %) | 23 (65.7 %) | |
Edmondson grade | 0.003 | |||
Low (I/II) | 82 | 32 (39.0 %) | 50 (61.0 %) | |
High (III/IV) | 86 | 56 (65.1 %) | 30 (34.9 %) | |