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Table 1 Relationship between CTSB expression and clinicopathologic features of HCC patients

From: Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients

Clinicopathologic parameters n CTSB expression P value
Positive (%) Negative (%)
All cases 168 90 (53.5 %) 78 (46.5 %)  
Gender     0.562
   Male 110 57 (51.8 %) 53 (48.2 %)  
   Female 58 32 (55.2 %) 26 (44.8 %)  
Age (years)     0.310
   <50 123 61 (49.6 %) 62 (50.4 %)  
   ≥50 45 26 (57.8 %) 19 (42.2 %)  
Tumor size (cm)a     0.622
   <5 131 71 (54.2 %) 60 (45.8 %)  
   ≥5 37 19 (51.4 %) 18 (48.6 %)  
Serum HBsAg     0.125
   Positive 147 82 (55.8 %) 65 (44.2 %)  
   Negative 21 10 (47.6 %) 11 (52.4 %)  
Serum AFP (ng/ml)     0.814
   <25 50 25 (50.0 %) 25 (50.0 %)  
   ≥25 118 60 (50.8 %) 58 (49.2 %)  
Cirrhosis     0.078
   Presence 145 78 (53.8 %) 67 (46.2 %)  
   Absence 23 10 (43.5 %) 13 (56.5 %)  
UICC stage     0.004
   I + II 100 32 (32.0 %) 68 (68.0 %)  
   III + IV 68 48 (70.6 %) 20 (29.4 %)  
Metastasis/Recurrence     0.000
   Yes 133 88 (66.2 %) 45 (33.8 %)  
   No 35 12 (34.3 %) 23 (65.7 %)  
Edmondson grade     0.003
   Low (I/II) 82 32 (39.0 %) 50 (61.0 %)  
   High (III/IV) 86 56 (65.1 %) 30 (34.9 %)  
  1. a:The largest dimension of the tumor specimen