Table 3 Cox regression analysis of patients with HCC
From: Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients
Variables | Univariate | P value | |
|---|---|---|---|
HR | CI (95 %) | ||
CTSB expression (1 = down,2 = over) | 5.132 | 3.125 ~ 6.037 | 0.000 |
Gender (1 = male,2 = female) | 0.511 | 0.327 ~ 1.078 | 0.106 |
Age (1 < 50,2 ≥ 50) | 0.468 | 0.279 ~ 0.998 | 0.412 |
Serum HBsAg (1 = negative,2 = positive) | 1.033 | 0.723 ~ 2.411 | 0.107 |
Serum AFP (1 < 25 ng/ml,2 ≥ 25 ng/ml) | 3.415 | 2.379 ~ 4.866 | 0.009 |
Tumor size (1 < 5 cm,2 ≥ 5 cm) | 1.756 | 1.218 ~ 3.321 | 0.039 |
Cirrhosis (1 = Absence,2 = Presence) | 0.932 | 0.782 ~ 1.687 | 0.443 |
Metastasis/Recurrence (1 = no,2 = yes) | 5.002 | 3.437 ~ 7.312 | 0.000 |
UICC stage (1 = I + II,2 = III + IV) | 1.958 | 1.021 ~ 4.190 | 0.042 |
Edmondson grade (1 = High (III/IV),2 = Low (I/II)) | 1.412 | 0.783 ~ 2.224 | 0.098 |