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Fig. 5 | Molecular Cancer

Fig. 5

From: ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells

Fig. 5

Comparison of ERK activation in cell lines of differential Ras/Raf mutational status. SW480, HCT116, Colo320 DM and Caco 2 cell lines were treated with DAT1 (~1.5 times IC50 concentrations). ERK or DR5 activation was checked by western blotting after probing with the respective antibodies. The band intensities were normalized to the levels of actin and P-ERK/ERK ratios were found out

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Molecular Cancer

ISSN: 1476-4598