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Fig. 6 | Molecular Cancer

Fig. 6

From: ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells

Fig. 6

Effect of DAT1 on colon cancer xenografts. HCT116/HCT116 p53 −/− cells were injected subcutaneously into SCID/NOD mice. Once the tumour volume reached about 20–80 mm3, DAT1 was administered intraperitoneally. a. Photographs of SCID mice showing decreased tumour size upon DAT1 treatment. b. Tumour volumes were measured weekly both in control and the treated tissues and were plotted against the number of days. The statistical significance of differences in tumour volumes upon treatment are denoted as * for p ≤ 0.05, ** for p ≤ 0.01 and *** for p ≤ 0.001

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