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Fig. 3 | Molecular Cancer

Fig. 3

From: Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment

Fig. 3

Emerging preliminary evidence implicates Hh signaling activation in immune system suppression as a result of the pathway’s ability to downregulate MHC I which suppresses cytotoxic T cell tumor cell clearance, upregulate SOCS1 which inhibits STAT1 signaling, and upregulate STAT6 which promotes T cell polarization toward the Th2 phenotype. All three properties result in diminished immune system function against tumors and the promotion of pro-tumorigenic functions by T cells

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