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Fig. 5 | Molecular Cancer

Fig. 5

From: ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models

Fig. 5

Manipulation of ITGA6 levels directly impacts invasion. a Non-sorted, cultured shControl or shHIF1A/shHIF2A MDA-MB-231 cells were evaluated for invasive potential using Boyden chamber assays. The grand mean of the invasion index (invasion corrected for random migration) ± SEM of 3 independent experiments is shown; p-values calculated by Student’s t-test are indicated. b Knockdown of ITGA6 impairs invasion at normoxia and hypoxia. The grand mean of the invasion index (invasion corrected for random migration) ± SEM of 3 independent experiments is shown; p-values were calculated by Student’s t-test. c Ectopic expression of ITGA6 in shHIF1A/shHIF2A cells partially rescues invasion at hypoxia. The grand mean of the invasion index (invasion corrected for random migration) ± SEM of 3 independent experiments is shown; p-values were calculated by Student’s t-test.

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Molecular Cancer

ISSN: 1476-4598