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Table 1 ELDA analysis of TIC frequency at day 51 post-transplant for the CD49fNeg/CD24Low or CD49f+/CD24High sorted cell populations isolated from MMTV-PyMT+ tumors that were implanted into the cleared mammary fat pad of recipient mice at low density; the number of animals producing tumors/the number of animals transplanted is also indicated

From: ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models

 

Sorted population:

 

Number of cells injected:

CD49fNeg/CD24Low

CD49f+/CD24High

p-value:

200

2/7 (29 %)

5/7 (71 %)

 

100

1/6 (17 %)

4/6 (67 %)

 

50

1/8 (12 %)

6/9 (67 %)

 

25

0/8 (0 %)

1/8 (12 %)

 

Estimated TIC Frequency

1/578

1/99

 

(95 % C.I.)

(1/216 to 1/1,544)

(1/58 to 1/170)

0.00043