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Fig. 7 | Molecular Cancer

Fig. 7

From: Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death

Fig. 7

DMH1 together with TGFβ inhibition induces cell death and downregulates pTAK1 that is greatest when XIAP is knocked down. BMPRII regulates XIAP expression. a H1299 cells were treated with control siRNA and siRNA targeting XIAP and treated with DMH1 and the TGFβ inhibitor LY2109761 (LY) (n = 3). Cells with knockdown of XIAP and treated with DMH1 and LY demonstrated the greatest percentage of cell death. (b) Western blot analysis showing that H1299 cells with knockdown of XIAP and treated with both DMH1 and LY had the greatest decrease in expression of pTAK1 (n = 4). (c) Western blot analysis demonstrating knockdown of BMPRII in H1299 cells with siRNA decreases the expression of XIAP (n = 4)

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Molecular Cancer

ISSN: 1476-4598