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Table 1 IC50

From: Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death

Half maximal inhibitory concentration (IC50)

 

Alk2/ACVRR1

(nM)

Alk3/BMPR1A

(nM)

Alk6/BMPRII

(nM)

BMPRII

(nM)

Alk5/TGFbetaR1

(nM)

TGFbetaR2

(nM)

DMH2

23

92

43

7,950

1,690

193

 

DMH1

108

5

(35)

(35)

LDN

5

20

3

185

151

 
  1. Inhibition of kinase activity of BMP and TGF beta receptors was determined for DMH2 and compared to DMH1 and LDN