From: Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death
Half maximal inhibitory concentration (IC50)
Alk2/ACVRR1
(nM)
Alk3/BMPR1A
Alk6/BMPRII
BMPRII
Alk5/TGFbetaR1
TGFbetaR2
DMH2
23
92
43
7,950
1,690
193
DMH1
108
5
–
(35)
LDN
20
3
185
151