Fig. 4
From: A bioavailable cathepsin S nitrile inhibitor abrogates tumor development
Compound 6 blocks CD74 degradation in murine spleen and reduces progression in MC38 tumor model. a C57BL/6 mice were treated with 100 mg/kg compound 6 for 18 h before harvesting of spleens and subsequent analysis of CTSS substrate lip10 by western blot. Results demonstrated compound 6 to block CTSS degradation of lip10 in murine spleen (3 mice/group). b Treatment of MC38 tumors syngeneic model with compound 6 (on days indicated by black arrow) significantly reduced tumor volume over 16 days (*P<0.05;Â **P<0.01)