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Fig. 6 | Molecular Cancer

Fig. 6

From: Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma

Fig. 6

Regulation of target gene expression depending on miRNA methylation. a. Visualization of a statistical model relating target gene expression with methylation change of corresponding microRNAs stratified by three different levels of context++ score, which is an index determining the degree of matching. The effect of methylation change was estimated from coefficients for the relative methylation change. Methylation and expression levels of microRNAs in background tissues, and target gene methylation were also included as covariates. Green line: miRNA methylation, blue: miRNA expression, dark yellow: target gene methylation (promoter), yellow: target gene methylation (body). b. A similar analysis to Fig. 6a only applying the target genes targeted by clustered miRNAs within highly matched miRNA sites (context++ score < -0.6). c. Hierarchical clustering of expression of target genes targeted by clustered miRNAs with context++ score < -0.6. Blue dotted line is a border for tumor-background. A red arrow indicates a cluster characterized by tumor-specific overexpression of target genes. d. A similar analysis to Fig. 5b only applying target genes targeted by clustered miRNAs with context++ score < -0.6 (highest matching)

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