Fig. 2

Schematic representation of portion of the fusion Variant 2 of Rad51C-ATXN7. The fusion transcript and their breakpoints are indicated with exons of Rad51C and ATXN7. The Variant 2 of the fusion gene transcript is joined at 3′-end of exon-6 of Rad51C with 5′-end of the exon-6 of ATXN7. The Fusion protein has lost its nuclear localization signal located at the C-terminus end of Rad51C and CAG (Poly glutamine tract) repeat sequence of ATXN7. The ATP binding site and BRC (BRCA1) interacting domains of Rad51C are conserved at N-terminus of the fusion protein and SCA7 (Spino- cerebral ataxia 7) domain of ATXN7 conserved at middle terminus of the fusion protein