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Fig. 2 | Molecular Cancer

Fig. 2

From: Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Fig. 2

Cytotoxic effects resulting from YCW1 and/or IR in 4 T1 and MBA-MD-231 cells. a Concentration-dependent effects of YCW1 on the viability of 4 T1 and MBA-MD-231 cells. Cells were treated with 0.5, 1, 1.5 or 2 μM of YCW1 for 48 h. b Dose-dependent effects of IR on the viability of 4 T1 and MBA-MD-231 cells. Cells were treated with 2, 4, 6 or 8 Gy of IR for 48 h. *, p < 0.05, YCW1 or IR versus control group. c Cytotoxicity observed in cells treated with YCW1 (1 μM) and IR (4 Gy) for 48 h in 4 T1 and MBA-MD-231 cells. #, p < 0.05, IR versus combined treatment. *, p < 0.05, YCW1 versus combined treatment. Data are presented as the mean ± standard deviation of three independent experiments

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