Fig. 1

MiR-143-3p is downregulated in ESCC cell lines and tumor tissue, and is associated with poor prognosis. a Real time RT-PCR analysis of three most differentially downregulated miRNAs expression in four human ESCC cell lines and the normal esophageal epithelial cell line (HEEC). b Real time RT-PCR analysis of miR-143-3p expression in 80 human ESCC tissue samples and their matched normal tissues. Expression levels are shown in log2 scale. c Correlation between miR-143-3p expression and the overall survival of ESCC patients. Results are expressed as the mean ± SD of three independent experiments. *: P <0.05; **: P <0.01