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Fig. 7 | Molecular Cancer

Fig. 7

From: MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial–mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma

Fig. 7

Restoration of QKI-5 reverses miR-143-3p-mediated inhibition of ESCC cell growth and metastasis. a, b MTT and colony formation assays were conducted to evaluate the proliferative capacity of ESCC cells. c Flow cytometric analysis of Annexin V-FITC staining was used to quantify apoptosis rate in miR-143-3p and miR-143-3p/pLenti QKI-5 group cells. d Migration and invasion assay were conducted in ESCC cells transfected with miR-143-3p or co-transfected with pLenti QKI-5. e Wound healing assays were used to evaluate the motility of ESCC cells transfected with miR-143-3p alone or co-transfected with pLenti QKI-5. Results are expressed as the mean ± SD of three independent experiments. *: P <0.05;**: P <0.01

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