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Fig. 8 | Molecular Cancer

Fig. 8

From: RETRACTED ARTICLE: MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial–mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma

Fig. 8

MiR-143-3p inhibits ESCC cells growth by inhibiting QKI-5 in vivo. a Effects of miR-143-3p on tumor growth in nude mice. Growth curves and weights of tumors resulted from injection of Kyse70 cells stably expressing with miR-143-3p in nude mice. Apoptosis was evaluated by performing a TUNEL assay using sections of the transplanted tumors (×200). b Effect of QKI-5 on tumor growth in nude mice. Xenograft assay with Kyse70 stable cells revealed that inhibition of QKI-5 decreased the volume of the xenograft tumors, while restoration of QKI-5 showed a proliferative tendency with significantly greater tumor volume. c Restoration of QKI-5 significantly reversed the suppression of tumor growth and apoptosis induced by miR-143-3p. *: P <0.05; **: P <0.01

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Molecular Cancer

ISSN: 1476-4598