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Fig. 3 | Molecular Cancer

Fig. 3

From: Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

Fig. 3

The hedgehog (Hh)/GLI inhibitor GANT61 reduced the viability and sphere formation of pancreatic cancer cells; PANC-1 is a less sensitive cell line. a, b The hedgehog (Hh)/GLI inhibitor GANT61, but not the Hh/SMO inhibitor cyclopamine, significantly reduced the viability of pancreatic cancer cells. The results are presented as percentages of control values in untreated cells, showing the mean and standard deviation (s.d.) of 4 replicates obtained in 1 representative experiment out of 3. Closed circle: Capan-1 M9. Open circle: PANC-1. c GANT61 reduced the sphere formation of Capan-1 M9 cells in a single cell sphere formation assay. We determined the number of spheres formed per 96-well plate in triplicate. All data are mean and s.d. in 1 representative experiment out of 2. d GANT61 reduced the sphere formation of PANC-1 cells at a higher concentration. The results are presented as (c). *P < 0.05

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Molecular Cancer

ISSN: 1476-4598