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Fig. 1 | Molecular Cancer

Fig. 1

From: Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer

Fig. 1

Determination of cut-off values of PD-1 and PD-L1 expressions in TCGA database and survival analyses. X-tile analysis of 5-year OS was performed using patients’ data in TCGA database to determine the optimal cut-off value for PD-1 and PD-L1 expression. The sample of CRC patients was equally divided into training and validation sets. X-tile plots of training sets are shown in the left panels, with plots of matched validation sets shown in the smaller inset. The optimal cut-off values highlighted by the black circles in left panels are shown in histograms of the entire cohort (middle panels), and Kaplan-Meier plots are displayed in right panels. P values were determined by using the cut-off values defined in training sets and applying them to validation sets. a The optimal cut-off value for PD-1 was 4.40 (χ2 = 4.591, P = 0.032). b The optimal cut-off value for PD-L1 was 2.92 (χ2 = 9.349, P = 0.002)

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