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Table 2 Univariate and multivariate Cox proportional hazards analysis of OS for patients with CRC in the TCGA cohort

From: Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer

Variablesa Univariate analysis HR (95 % CI) P b Multivariate analysis HR (95 % CI) P b
Age (years)
  ≤ 60 1.000 0.202 1.000 0.937
  > 60 1.366 (0.846–2.204)   1.021 (0.606–1.720)
Gender
 Male 1.000 0.132 1.000 0.205
 Female 0.687 (0.421–1.120)   0.718 (0.431–1.198)
Tumor location
 Colon 1.000 0.149   
 Rectum 0.580 (0.277–1.215)   
Histological type
 Adenocarcinoma 1.000 0.148   
 Mucinous/SRCC 1.611 (0.844–3.076)   
T stage
 Tis-T2 1.000 <0.001 1.000 <0.001
 T3 1.463 (0.618–3.465)   0.832 (0.330–2.053)
 T4 8.584 (3.316–22.222)   2.912 (1.242–8.093)
N stage
 N0 1.000 <0.001 1.000 0.583
 N1 2.311 (1.306–4.091)   1.430 (0.724–2.823)
 N2 3.098 (1.718–5.588)   1.213 (0.557–2.642)
M stage
 M0 1.000 <0.001 1.000 0.115
 M1 4.013 (2.252–7.152)   2.062 (1.007–4.221)
 Mx 1.996 (1.083–3.676)   1.701 (0.837–3.458)
Venous invasion
 Negative 1.000 0.006 1.000 0.145
 Positive 2.411 (1.400–4.151)   2.008 (1.000–4.033)
 Unknown 1.625 (0.842–3.137)   1.362 (0.655–2.830)
TILs extent
 Low 1.000 0.541   
 High 0.746 (0.357–1.558)   
 Unknown 0.737 (0.422–1.286)   
No. of LNs dissected
  < 12 1.000 0.145   
  ≥ 12 2.311 (0.542–9.853)   
 Unknown 1.432 (0.347–5.917)   
MS status
 MSS 1.000    
 MSI 1.159 (0.710–1.892) 0.557  
CEA (μl/ml)
  ≤ 5 1.000   1.000 0.011
  > 5 2.146 (0.978–4.708) 0.003 1.339 (0.582–3.081)
 Unknown 3.086 (1.617–5.891)   2.778 (1.337–5.772)
PD-1
 Low 1.000   1.000 0.68
 High 0.591 (0.364–0.961) 0.034 0.883 (0.488–1.596)
PD-L1
 Low 1.000   1.000 0.148
 High 0.463 (0.279–0.768) 0.003 0.626 (0.332–1.181)
  1. aAll variables are djusted by Cox proportional hazards models including age, gender, T stage, N stage and M stage
  2. bItalic entries indicate statistical significance