Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer

Table 2 Univariate and multivariate Cox proportional hazards analysis of OS for patients with CRC in the TCGA cohort

Variables^a	Univariate analysis HR (95 % CI)	P ^b	Multivariate analysis HR (95 % CI)	P ^b
Age (years)
≤ 60	1.000	0.202	1.000	0.937
> 60	1.366 (0.846–2.204)		1.021 (0.606–1.720)	0.937
Gender
Male	1.000	0.132	1.000	0.205
Female	0.687 (0.421–1.120)		0.718 (0.431–1.198)	0.205
Tumor location
Colon	1.000	0.149
Rectum	0.580 (0.277–1.215)
Histological type
Adenocarcinoma	1.000	0.148
Mucinous/SRCC	1.611 (0.844–3.076)
T stage
Tis-T2	1.000	<0.001	1.000	<0.001
T3	1.463 (0.618–3.465)		0.832 (0.330–2.053)
T4	8.584 (3.316–22.222)		2.912 (1.242–8.093)
N stage
N0	1.000	<0.001	1.000	0.583
N1	2.311 (1.306–4.091)		1.430 (0.724–2.823)
N2	3.098 (1.718–5.588)		1.213 (0.557–2.642)
M stage
M0	1.000	<0.001	1.000	0.115
M1	4.013 (2.252–7.152)		2.062 (1.007–4.221)
Mx	1.996 (1.083–3.676)		1.701 (0.837–3.458)
Venous invasion
Negative	1.000	0.006	1.000	0.145
Positive	2.411 (1.400–4.151)		2.008 (1.000–4.033)
Unknown	1.625 (0.842–3.137)		1.362 (0.655–2.830)
TILs extent
Low	1.000	0.541
High	0.746 (0.357–1.558)
Unknown	0.737 (0.422–1.286)
No. of LNs dissected
< 12	1.000	0.145
≥ 12	2.311 (0.542–9.853)
Unknown	1.432 (0.347–5.917)
MS status
MSS	1.000
MSI	1.159 (0.710–1.892)	0.557
CEA (μl/ml)
≤ 5	1.000		1.000	0.011
> 5	2.146 (0.978–4.708)	0.003	1.339 (0.582–3.081)
Unknown	3.086 (1.617–5.891)		2.778 (1.337–5.772)
PD-1
Low	1.000		1.000	0.68
High	0.591 (0.364–0.961)	0.034	0.883 (0.488–1.596)	0.68
PD-L1
Low	1.000		1.000	0.148
High	0.463 (0.279–0.768)	0.003	0.626 (0.332–1.181)	0.148

^aAll variables are djusted by Cox proportional hazards models including age, gender, T stage, N stage and M stage
^bItalic entries indicate statistical significance

ISSN: 1476-4598