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Fig. 2 | Molecular Cancer

Fig. 2

From: Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches

Fig. 2

Importance of Wnt/miRNA network in the regulation of cancer stem-like cells. The Wnt-signalling (canonical & non-canonical) pathway governs the activity of some stem cell-specific miRNAs which plays crucial roles in tumour initiation and development. Aberrant Wnt-signalling could activate oncogenic miRNA expression which in-turn enhances the self-renewal potential of CSCs with subsequent expansion of the CSC pool which gives rise to cancer cells that possess self-renewing ability, resistance to drug therapy and ability to instigate new tumour growth

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