Fig. 3

Bioinformatics pathway for the characterization of Wnt-signalling regulated miRNAs and their targets. Summary of a proposed stepwise bioinformatics approach for the characterization of Wnt-regulated miRNAs. Due to the fact that canonical Wnt pathway is driven by several components; key components such as β-catenin can be utilized to identify potential miRNA regulators. Programmes and tools such as Benjamin-Hochberg [210], iCLIP [211], miRDeep [212] have all been used to perform bioinformatics analysis for different experiments. Image adapted from [213]. Note: β-catenin is a major transducer in the canonical Wnt-signalling pathway hence; the proposed stepwise bioinformatics approach can be applied to the study of network of miRNA and other key components of either the canonical or non-canonical signalling pathway