A long non-coding RNA signature to improve prognosis prediction of gastric cancer

Zhu, Xiaoqiang; Tian, Xianglong; Yu, Chenyang; Shen, Chaoqin; Yan, Tingting; Hong, Jie; Wang, Zheng; Fang, Jing-Yuan; Chen, Haoyan

doi:10.1186/s12943-016-0544-0

Molecular Cancer

Table 1 LncRNAs significantly associated with the disease free survival in the test series patients (N = 180)

From: A long non-coding RNA signature to improve prognosis prediction of gastric cancer

Probe	Gene symbol	Permutation P value^a,b	Hazard ratio^a	Coefficient^a	VI	Associated diseases	Description
233512_at	AF035291	0.0017	8.325	2.11846	0.012	NR	hypothetical LOC100287216
1568854_at	AI028608	0.0084	6.839	1.92247	−0.002	NR	non-protein coding RNA 240
229280_s_at	AK026189	6.00E-04	4.633	1.53266	0.006	Melanoma and basal cell carcinoma	promotes metastasis and recurrence of melanoma
1559412_at	H04858	8.00E-04	4.030	1.3926	0.002	Acute megakaryoblastic leukemia	Maintenance of leukemic growth
1559965_at	BC037827	0.0018	3.587	1.27718	0.053	NR	hypothetical LOC100192378
1557338_x_at	BC038210	0.0108	3.326	1.20171	0.017	NR	NR
230589_at	AI916498	0.0034	2.844	1.04591	−0.006	Gastric cancer	Sensitivity of iodine-125 particle irradiation and regulation of NF-KB signaling pathway
239466_at	AA463827	0.0013	2.799	1.0294	0.026	NR	hypothetical LOC344595
230251_at	AA041523	0.0014	2.521	0.92436	0.038	Non-small cell lung cancer	Associated with loss function of LKB1 gene
225029_at	BE621082	0.0016	2.249	0.81047	0.007	Systemic lupus erythematosus	A novel susceptibility locus on Xp11.21
1564139_at	AK056852	0.0016	1.923	0.65369	0.004	NR	hypothetical LOC144571
229014_at	AW206234	0.0021	1.718	0.54056	0.002	NR	hypothetical LOC441094
1558828_s_at	AL703532	0.0032	1.325	0.2811	0.005	Heart failure associated diseases	Regulation of cardiac cell differentiation and homeostasis
235759_at	AI095542	0.0034	1.282	0.24825	−0.004	NR	NR
213972_at	AI080288	0.0036	0.155	−1.86125	−0.007	NR	NR
1554880_at	BC021187	0.0024	0.106	−2.24862	−0.002	Gastric cancer	Protective roles for gastric cancer
235824_at	BF238392	0.0019	0.073	−2.61423	0.012	NR	NR
232191_at	BC005107	0.0076	0.070	−2.65478	0.002	NR	chromosome 21 open reading frame 105
1563296_at	BC039674	0.0022	0.068	−2.69258	0.000	NR	NR
239617_at	AI056187	9.00E-04	0.061	−2.79863	−0.001	Gastric cancer	spans the promoter and untranslated regions\of the ghrelin gene
243975_at	T79746	0.0031	0.058	−2.85076	0.003	NR	NR
1558666_at	H11436	3.00E-04	0.055	−2.89127	−0.007	NR	NR
237471_at	BF511694	0.0034	0.041	−3.19733	0.003	NR	hypothetical LOC154822
1562683_a_at	BC035722	0.0023	0.033	−3.40924	0.001	NR	hypothetical LOC285547

Abbreviations: VI Variable Importance, NR Not Reported
^aDerived from the univariable Cox proportional hazards regression analysis in the 180 test series patients
^bObtained from permutation test repeated 10,000 times

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ISSN: 1476-4598

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