Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis

Table 2 LncRNAs with experimental data supporting the functions of inhibiting tumor invasion and metastasis

LncRNAs	Source (Tissues and/or cells)	Expression in patients	Related genes	Experimental data	Function	References
BANCR	SCLC cell lines	Decreased	p38 MAPK, JNK	Inhibit cell proliferation, decrease invasion and metastasis	TS	[107]
DRAIC; PCAT29	PCa			Inhibit tumorigenicity and cell proliferation, decrease invasion and metastasis	TS	[14, 108]
TSLC1-AS1; ADAMTS9-AS2; CASC2	Glioblastoma, Glioma	Decreased	DNMT1, miR-21	Inhibit cell proliferation, decrease invasion and metastasis, induce cell apoptosis	TS	[109–111]
LCE5A-1; KCTD6-3	HNSCC	Decreased	EMT related genes	Reduce cell proliferation and metastasis, associated with the prognosis	TS	[112]
GAS5; CADM1-AS1	RCC, ccRCC	Decreased	CADM1	Inhibit cell proliferation and cell growth, decrease migration and invasion, induce apoptosis and cell cycle arrest	TS	[113, 114]
PTENP1	HCC	Decreased	PI3K/AKT pathway	Inhibit tumor growth and cell proliferation, cell invasion and migration, induce cell autophagy and apoptosis	TS	[115]
FENDRR	GC	Decreased	FN1, MMP2, MMP9	Inhibit cells invasion and migration	TS	[116]
ENST00000480739; Meg3	PDAC, PNETs	Decreased	c-Met	Prevent cell proliferation and delay cell cycle, decrease cell migration, invasion and metastasis	TS	[117, 118]

Abbreviations: SCLC small cell lung cancer, PCa prostate cancer, HNSCC head and neck squamous cell carcinoma, RCC renal cell carcinoma, ccRCC clear cell renal cell carcinoma, HCC hepatocellular carcinoma, GC gastric cancer, PDAC pancreatic ductal adenocarcinoma, PNETs pancreatic neuroendocrine tumors, TS tumor suppressor

ISSN: 1476-4598