Fig. 2
From: Synthetic lethality in lung cancer and translation to clinical therapies
Types of Synthetic Lethal Interactions in the Context of Cancer. The various types of synthetic lethal interactions can be grouped into two categories: genetic-based and chemical-based. Genetic synthetic lethality is primarily based on cancer-specific genetic alterations (blue normal cells undergo genetic changes that result in transformation to red cancer cells) that become susceptible to further induced changes in gene expression resulting in synthetic lethality. Chemical synthetic lethality describes synthetic lethal interactions between inherent or induced genetic alterations and broad-spectrum therapeutics (chemosensitization) as well as synergistic outcomes from the use of two or more chemotherapeutics. Please see text for full description of each type of interaction. (LOF = loss-of-function, GOF = gain-of-function, passenger A1 = passenger gene deletion, A2 = isoform of deleted passenger A1, blue cell = normal cell, red cell = cancer cell, grey cell = dead cancer cell)