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Fig. 2 | Molecular Cancer

Fig. 2

From: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing

Fig. 2

Morphology and tNGS amplicon coverage of investigated primary tumours and distant metastases of the CRC cases. a The panels depict H&E sections of case-matched primary tumours, and synchronous and/or metachronous liver or lung metastasis of three representative cases. Note areas of necrosis (“nec”; e.g. case #8, synM(HEP)) and widely distributed clusters of few tumor cells (e.g. case #6, metM(HEP)), necessary for interpretation of gene mutations with lower allele frequencies. All panels same magnification 2.5x except case #6 metM(HEP) being 10x. b Summary of the amplicon coverage for all 70 investigated DNA samples of the CRC cohort. Refer to the main text, Table 1 and Additional file 1: Table S2 for further details

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Molecular Cancer

ISSN: 1476-4598