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Fig. 3 | Molecular Cancer

Fig. 3

From: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing

Fig. 3

Case-matched shared mutations in primary tumours and distant metastases of CRC cases. The panels depict Venn diagrams of variants detected per case in primary tumour (blue), synchronous (yellow) and metachronous (orange) liver metastasis as well as synchronous (light green) and metachronous (dark green) lung metastases. Numbers represent the number of sequence variants being shared (overlaps) or separate for a specific CRC tissue specimen. Note that CRC cases #4, #5 and #14 exhibited mutations in the primary tumour, which were then also all detected in distant metastases and are hence only depicted in the overlaps. Note three patterns of CRC cases: type I = cases #2, 4, 5, 8, 11, 12, 13, 14; type II = # 6, 10, 1 and type III = #3, 7, 9. These three types did not correlate with the specific clinico-pathological or molecular features. Refer to main text for details

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Molecular Cancer

ISSN: 1476-4598