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Fig. 5 | Molecular Cancer

Fig. 5

From: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing

Fig. 5

Morphology of case-matched separate CRC metastatic liver or lung lesions resected at one time point with similar or distinct mutation profiles. The panels show H&E stainings of primary tumours and their associated resected liver or lung metastases, from which each two topographically distant located separate lesions (labelled lesion A and lesion B) were individually analyzed by tNGS. Case # 14 showed the same mutation profile in the primary tumour and its associated two metastatic liver lesions (within segments 5 and 7). Cases #13 (upper, lower lobes of lung) and cases #3 (segments 7 and 8) each showed only few shared mutations and numerous additional mutations associated with either of the individual lung metastatic lesions, despite similar morphology. Refer to main text for details

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