Molecular Cancer

Table 4 Case-mixed analysis of tumour site specific mutations

From: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing

Gene	Variant	PT - Colon	PT - Rectum	syn M[HEP]	syn M[PUL]	met M[HEP]	met M[PUL]
ABL1	p.315S	0	0	0	2	0	0
APC	p.R876*	2	0	0	0	0	3
	p.R1114*	0	0	0	0	0	4
	p.E1284*	0	0	0	2	0	0
	p.Q1338*	0	0	0	2	0	0
ATM	p.A1812V	0	0	2	0	0	0
ERBB4	p.D300N	0	0	0	2	0	0
FGFR3	p.T722I	0	0	0	0	2	0
PDGFRA	p.P577S	1	1	0	0	0	0
PTEN	p.Q171*	2	0	0	0	0	0
PTEN	p.H185Y	1	1	0	0	0	0
SMAD4	p.R361C	0	0	0	2	0	0
TP53	p.W91*	0	0	0	0	0	2
	p.175H	0	0	2	0	0	0
	p.V157F	0	0	0	0	2	0
	p.R196*	0	0	0	0	0	3
	p.R282W	0	0	0	0	0	3
	p.R273C	0	0	0	0	0	2

The table presents the gene variants detected in at least 2 samples per tumour site further to KRAS and NRAS, as analyzed in a case-mixed manner and with exclusion of known SNPs

Back to article page

ISSN: 1476-4598

Contact us

General enquiries: journalsubmissions@springernature.com