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Table 4 Case-mixed analysis of tumour site specific mutations

From: Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing

Gene Variant PT - Colon PT - Rectum syn
M[HEP]
syn
M[PUL]
met
M[HEP]
met
M[PUL]
ABL1 p.315S 0 0 0 2 0 0
APC p.R876* 2 0 0 0 0 3
p.R1114* 0 0 0 0 0 4
p.E1284* 0 0 0 2 0 0
p.Q1338* 0 0 0 2 0 0
ATM p.A1812V 0 0 2 0 0 0
ERBB4 p.D300N 0 0 0 2 0 0
FGFR3 p.T722I 0 0 0 0 2 0
PDGFRA p.P577S 1 1 0 0 0 0
PTEN p.Q171* 2 0 0 0 0 0
p.H185Y 1 1 0 0 0 0
SMAD4 p.R361C 0 0 0 2 0 0
TP53 p.W91* 0 0 0 0 0 2
p.175H 0 0 2 0 0 0
p.V157F 0 0 0 0 2 0
p.R196* 0 0 0 0 0 3
p.R282W 0 0 0 0 0 3
p.R273C 0 0 0 0 0 2
  1. The table presents the gene variants detected in at least 2 samples per tumour site further to KRAS and NRAS, as analyzed in a case-mixed manner and with exclusion of known SNPs