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Fig. 1 | Molecular Cancer

Fig. 1

From: Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1

Fig. 1

Effect of esculetin on pancreatic cancer cells: A Effect of different concentrations of esculetin on cell viability using MTT assay in PANC-1, AsPc-1 and MIA PaCa-2 cell lines. B Cell cycle analysis of different cell lines ((I) PANC-1 (II) AsPc-1 and (III) MIA PaCa-2) in the absence and presence of esculetin (100 μM) using flow cytometric analysis of DNA content showing cell cycle arrest in G1 phase (a-synchronized population, b-vehicle control, c- esculetin treated cells for 12 h in I and II and 18 h in III). C Percent distribution of PANC-1 cells in different phases of cell cycle upon 100 μM esculetin treatment. (V stands for Vehicle control for indicated time, E stands for esculetin treated sample for indicated time). Data represents the mean ± SD of three independent experiments. The significance was determined using ANOVA (Bonferroni’s test). Key:*p < 0.05; **p < 0.01; ***p < 0.001; **** p < 0.0001)

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Molecular Cancer

ISSN: 1476-4598