Fig. 1
From: Systems analysis identifies miR-29b regulation of invasiveness in melanoma
Systems analysis of database-enriched statistical associations between miR and mRNA transcripts. a Density and contour plot for mutual information and Pearson’s correlation between transcript abundance of all miR and mRNA pairs across the LM-MEL cell line panel (n = 57). Associations within the top 10% of mutual information values (vertical dashed line) and bottom (most negative) 2.5% of Pearson’s correlation values (horizontal dashed lines) were selected as those with strong negative associations (relative fraction of associations in red). b These associations (a, bottom right) were matched against high-confidence, predicted relationships from TargetScan and DIANA-microT, and previously validated relationships from miRTarBase. Relationships between hsa-miR-29b-3p and LAMC1, LASP1, and PPIC are examined below, Additional file 3 lists all putative relationships