From: Caveolin-1 in the regulation of cell metabolism: a cancer perspective
CAV1 promoted or directly correlated with metabolic processes | Ref. | CAV1 suppressed or inversely correlated with metabolic processes | Ref. |
---|---|---|---|
Glycolysis | |||
 •Colon cancer [HCT116, HT29, LoVo]*  •Prostate cancer [LNCaP, PC-3]  Smooth muscle cells, lymphocytes | 47, 48 49 51 | BAEC CA fibroblast [hTERT–BJ1] Breast cancer cell [MCF7] Mouse liver (including gluconeogenesis) | 52 55 56 58 |
Mitochondrial function | |||
 BAEC  Hepatic cells  Microglia  Colon cancer [HCT116, HT29]  MEFs | 52 59 60 61 57, 62 | NIH3T3 cells oncogenically transformed with H-RAS mutant | 43 |
Glutamine metabolism | |||
  Xenopus laevis oocyte | 70 | Stromal fibroblast; [hTERT–BJ1] | 64, 103 |
Fatty acid metabolism | |||
 BAEC | 52 | – | – |
 Mouse liver | 57, 58, 82 |  |  |
 Mouse hepatocyte [AML12] | 58 |  |  |
 Adipocytes | 57, 82 |  |  |
 MEFs | 57, 82 |  |  |
 Melanoma, prostate cancer | 76, 77, 78 |  |  |
Metabolic diseases | |||
 Obesity: |  | Diabetes: |  |
 Adipose tissues of patients | 96 | Insulin insensitivity, hyperglycemia | 57 |
 Murine preadipocyte model [3T3-L1] | 95 | Insulin resistance (Type 2 diabetes) | 94 |
 High fat diet mouse model | 97 |  |  |
Autophagy | |||
 Breast cancer cell [BT474] treated with estradiol | 109 | BAEC | 52 |
 Lung epithelial cells [BEAS-2B] | 110 | •Hepatocellular carcinoma [HCCLM3]* | 104 |
 •Renal carcinoma cell [786-O, A498]* | 111 | •Breast cancer [MCF7, MDA-MB-231]* | 107 |
 Murine fibrotic lung tissue | 112 | MEFs | 107 |
 Lung cancer cell [A549] | 113 | CA fibroblast [hTERT–BJ1] | 108 |