Caveolin-1 in the regulation of cell metabolism: a cancer perspective

Table 1 Cell, tissue types and disease conditions in which CAV1 was found to correlate with or influence metabolic processes

CAV1 promoted or directly correlated with metabolic processes	Ref.	CAV1 suppressed or inversely correlated with metabolic processes	Ref.
Glycolysis
•Colon cancer [HCT116, HT29, LoVo]* •Prostate cancer [LNCaP, PC-3] Smooth muscle cells, lymphocytes	47, 48 49 51	BAEC CA fibroblast [hTERT–BJ1] Breast cancer cell [MCF7] Mouse liver (including gluconeogenesis)	52 55 56 58
Mitochondrial function
BAEC Hepatic cells Microglia Colon cancer [HCT116, HT29] MEFs	52 59 60 61 57, 62	NIH3T3 cells oncogenically transformed with H-RAS mutant	43
Glutamine metabolism
Xenopus laevis oocyte	70	Stromal fibroblast; [hTERT–BJ1]	64, 103
Fatty acid metabolism
BAEC	52	–	–
Mouse liver	57, 58, 82
Mouse hepatocyte [AML12]	58
Adipocytes	57, 82
MEFs	57, 82
Melanoma, prostate cancer	76, 77, 78
Metabolic diseases
Obesity:		Diabetes:
Adipose tissues of patients	96	Insulin insensitivity, hyperglycemia	57
Murine preadipocyte model [3T3-L1]	95	Insulin resistance (Type 2 diabetes)	94
High fat diet mouse model	97
Autophagy
Breast cancer cell [BT474] treated with estradiol	109	BAEC	52
Lung epithelial cells [BEAS-2B]	110	•Hepatocellular carcinoma [HCCLM3]*	104
•Renal carcinoma cell [786-O, A498]*	111	•Breast cancer [MCF7, MDA-MB-231]*	107
Murine fibrotic lung tissue	112	MEFs	107
Lung cancer cell [A549]	113	CA fibroblast [hTERT–BJ1]	108

MEFs mouse embryonic fibroblasts, BAEC Bovine aortic endothelial cells, CA Cancer associated; •Including in clinical samples; In squared bracket [] are cell lines used for mechanistic studies; *other cell lines are mentioned in the studies

ISSN: 1476-4598