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Table 2 Mapping of somatic mutations from COSMIC to candidate regulatory regions (CRRs)

From: Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data

Title

All

Cancer census genes

Chosen CRRs

Rejected CRRs

Chosen CRRs

Rejected CRRs

Total number of CRRs

25045

158560

1140

7429

CRRs mutated at least once

3535 (14.11%)1

16241 (10.24%)1

160 (14.03%)2

703 (9.46%)2

Mean mutations/CRR

1.353

0.933

1.514

0.974

Mean mutations/CRR (models with r > 0.7)

1.403

0.883

1.635

0.955

Mean mutations/CRR (models with r > 0.8)

1.503

0.833

1.55

0.92

  1. 1Proportion mutated in chosen set greater than in rejected set, p < 10−15 (Chi-squared and Fisher test)
  2. 2Proportion mutated in chosen set greater than in rejected set, p < 10−5 (Chi-squared and Fisher test)
  3. 3Mean mutations in chosen set greater than in rejected set, p < 10−23 (two sample t test), p < 10−8 (Wilcoxon test)
  4. 4Mean mutations in chosen set greater than in rejected set, p < 0.05 (two sample t test and Wilcoxon test)
  5. 5Mean mutations in chosen set greater than in rejected set, p < 0.05 (two sample t test), p = 0.06 (Wilcoxon test)