Table 2 Correlation between EZH2, STAT3 and clinicopathologic features in GC
From: STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer
Characteristics | Cases n | EZH2 expression | P-value | STAT3 expression | P-value | |||
|---|---|---|---|---|---|---|---|---|
Low/- | High/+ | Low/- | High/+ | |||||
Age (y) | ≤60 | 22 | 6 | 16 | 0.804 | 11 | 11 | 0.024 |
> 60 | 41 | 10 | 31 | 9 | 32 | |||
Gender | Male | 47 | 15 | 32 | 0.043 | 17 | 30 | 0.200 |
Female | 16 | 1 | 15 | 3 | 13 | |||
Differentiation | Well | 11 | 5 | 6 | 0.164 | 3 | 8 | 0.658 |
Moderate | 13 | 4 | 9 | 3 | 10 | |||
Poor | 39 | 7 | 32 | 14 | 25 | |||
Borrmann’s pathologic classification | Ulceration | 47 | 10 | 37 | 0.342 | 15 | 32 | 0.678 |
Prominence | 7 | 2 | 5 | 3 | 4 | |||
Diffuse | 9 | 4 | 5 | 2 | 7 | |||
Tumor Location | Antrum | 45 | 11 | 34 | 0.785 | 14 | 31 | 0.865 |
Body & Cardia | 18 | 5 | 13 | 6 | 12 | |||
TNM stage | I | 12 | 8 | 4 | 0.002 | 10 | 2 | 0.0001 |
II | 13 | 4 | 9 | 3 | 10 | |||
III | 27 | 3 | 24 | 7 | 20 | |||
IV | 11 | 1 | 10 | 0 | 11 | |||
Lymph node metastasis | No | 30 | 12 | 18 | 0.051 | 14 | 16 | 0.016 |
Yes | 33 | 4 | 29 | 6 | 27 | |||
Distant metastasis | No | 53 | 13 | 40 | 0.738 | 18 | 35 | 0.388 |
Yes | 10 | 3 | 7 | 2 | 8 | |||