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Fig. 5 | Molecular Cancer

Fig. 5

From: MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit

Fig. 5

Schematic illustration of the RET oncogene-induced NF-κB-miR-182-HES1 axis that promotes cancer aggressiveness via inhibition of Notch signaling. Mutated RET activates NF-κB which induces miR-182 expression in the nucleus. Enhanced miR-182 represses the negative transcriptional regulator HES1 through binding to its 3′UTR. The inhibitory influence of HES1 on Dtx1, a suppressor of Notch, is attenuated with the consecutive effect of reducing Notch1 level in the cells. As consequence, Notch1 cannot exhibit its tumor suppressor function in MTC, leading to a more malignant phenotype

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