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Fig. 1 | Molecular Cancer

Fig. 1

From: Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition

Fig. 1

LCN2 expression in CRC cells and tissues. a Reverse transcription-polymerase chain reaction (RT-PCR) and western blots of LCN2 expression in the indicated CRC cell lines. b LCN2 expression (upper), and quantification of LCN2 positive rates (lower) in CRC primary lesions and metastatic lymph node lesions (*** P < .001). c Western blots of LCN2 expression in CRC tissues compared with matched corresponding normal tissues (T, tumor; N, normal). d Quantification of LCN2 mRNA expression of normal and tumor tissues in TCGA database (* P < .05). (E) Expression of EMT markers (E-cadherin (membrane; n = 108, P = .036; r = 0.213) and β-catenin (nuclear; n = 122, P = .017; r = −0.215) and LCN2 detected by immunohistochemistry in 2 cases of CRC. In case 1, the staining of LCN2 and E-cadherin was weak, as well as membranous β-catenin, but the staining of neuclear β-catenin was strong. Contrary to case 1, the expression of LCN2, E-cadherin, and membranous β-catenin was strong but nuclear β-catenin was weak in case 2. (scale bars, 100 μm)

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