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Table 1 Differentiation of RCC subtypes

From: Choosing the right cell line for renal cell cancer research

Marker Clear cell RCC Papillary RCC Type 1 Papillary RCC Type 2 Chromophobe RCC Oncocytoma Xp11.2 translocation RCC
VHL mutation + (~90%) - - - - -
cMET mutation - + - - - -
TP53 mutations - - - + - -
Other mutations PBRM1 (~50%), BAP1 (~15%), SETD2 (~15%) NRF2, CUL3 FH - Mitochondrial complex I genes translocations of Xp11.2 (TFE3) or 6p21 (TFEB)
CK8 +/- + + +/- + ND
CAIX + +/- + - - +
CAM 5.2 + + + + + -
CD10 + + + +/- +/- +
CD15 + + + - + ND
CK18 + + + + + ND
EMA + + + + + -
GST-alpha + - - - - ND
PAX2 + + +/- - + +/-
PAX8 + + + + - +
RCC Ma + + +/- - - +
VIM + + + - - +
AMACR - + + - - +
CD117 - - - + + ND
CK7 - +/- -/+ +/- - +/-
CK19 - - - - - +/-
CK20 - - - - - -
c-KIT - +/- +/- + + ND
CLDN7/8 - - - + + ND
E-cadherin - + +/- + - +
EpCAM - - -/+ + +/- ND
Ksp-cad - - - - + +
PVALB - - - + +/- ND
TFE3 - - - - - +
SMA - - - - + ND
  1. Legend: AMACR α-methylacyl coenzyme A racemase, CAIX carbonic anhydrase IX, CK7 cytokeratin 7, CLDN7/8 claudin 7/8, EMA epithelial membrane antigen, GST-alpha glutathione S-transferase alpha, EpCAM epithelial cell adhesion molecule, Ksp-cad kidney-specific cadherin, PVALB parvalbumin, RCC Ma renal cell carcinoma marker, SMA smooth muscle action, TFE3 Transcription factor E3 - transcription factor binding to IGHM enhancer 3, PAX2/8 paired box gene 2/8, VIM vimentin, ND no reported data