Fig. 4
Knockdown TUG1 enhanced the chemosensitivity of SCLC cells to anticancer drugs both in vitro and in vivo. a The sensitivities of cells to chemotherapy drugs (CDDP, ADM or VP-16) were measured after H69AR and H446DDP cells transfected with siTUG1 by CCK-8 assay. b Tumors from all mice in each group (Each group has five mice). H446DDP cells were transduced with shControl or shTUG1 as indicated. After cells (3x107) were injected into mice, chemotherapeutics or PBS were injected intraperitoneally as indicated. c Growth curve of tumor volumes. d Tumor weights were determined. e qRT-PCR was conducted to detect the average expression of TUG1. *, P < 0.05; **, P < 0.001