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Fig. 1 | Molecular Cancer

Fig. 1

From: IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

Fig. 1

Schematic representation of the insulin and IGF receptor family. The IGF system consists of ligands (IGF-I, IGF-II and insulin), receptors (IGF-IR, IGF-II/ M6P, IR), and a family of six high-affinity IGFBPs. The IR exists in two splice variant isoforms, the IRA and IRB. Different receptors dimerize to form six receptor species those vary in their ligand affinity. Ligands binding to receptors can result in activation of different intracellular signaling cascades that regulate cell proliferation, survival, differentiation, and metabolism

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