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Fig. 6 | Molecular Cancer

Fig. 6

From: IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

Fig. 6

IGF-IR signaling in CSCs-like cells biology. Schematic summary of the IGF-IR signaling in the regulation of CSCs-like cells biology. After long term of EMT-associated factors effects, some of the EMT cells acquire CSCs-like properties with over-activation of IGF-IR signaling. IGF-IR/PI3K/Akt/mTOR signaling pathway activation increases the CSCs population, which promotes EMT process. The activation of IGF/STAT3/Nanog/Slug axis induces the progression of EMT and self-renewal of CSCs. CSCs, cancer stem cells; STAT3, signal transducer and activator of transcription 3; mTOR, mammalian target of rapamycin

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