Table 1 EMT markers, inducers and transcriptional factors
EMT markers | EMT inducers and pathways | EMT-TFs |
|---|---|---|
Epithelial markers | Â | Direct binding to E-cadherin promoter |
E-cadherin | RTKs (EGFR, FGFR, IGFR) | Snail1/2 |
Occludin | TGF-β | ZEB1/2 |
Desmoplakin | GSK-3β | KLF8 |
Cytokeratin | NK-κB | E47 |
Mucin1 | β-catenin | Brachyury |
TJP1 | Hypoxia/AMF | Repressing E-cadherin indirectly |
Mesenchymal markers | Ras-MAPK pathway | Twist1/2 |
Vimentin | PI3K/Akt pathway | FOXC2 |
Fibronectin | Src pathway | E2.2 |
N-cadherin | Notch pathway | SIX1 |
Thrombospondin | Wnt pathway | PRRX1 |
α-SMA | Shh pathway | Goosecoid |
Tenascin C | mTOR pathway | HDAC |
MMP family | STAT3 pathway | EZH2 |