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Table 1 EMT markers, inducers and transcriptional factors

From: IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights

EMT markers EMT inducers and pathways EMT-TFs
Epithelial markers   Direct binding to E-cadherin promoter
E-cadherin RTKs (EGFR, FGFR, IGFR) Snail1/2
Occludin TGF-β ZEB1/2
Desmoplakin GSK-3β KLF8
Cytokeratin NK-κB E47
Mucin1 β-catenin Brachyury
TJP1 Hypoxia/AMF Repressing E-cadherin indirectly
Mesenchymal markers Ras-MAPK pathway Twist1/2
Vimentin PI3K/Akt pathway FOXC2
Fibronectin Src pathway E2.2
N-cadherin Notch pathway SIX1
Thrombospondin Wnt pathway PRRX1
α-SMA Shh pathway Goosecoid
Tenascin C mTOR pathway HDAC
MMP family STAT3 pathway EZH2
  1. TJP1 tight junction protein 1, α-SMA α-smooth muscle actin, KLF8 Krüppel-like Factor 8, FOXC2 forkhead box C2, PRRX1 paired-related homeobox gene 1, HDAC histone deacetylase