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Table 3 Univariate and multivariate Cox regression analysis of overall survival in each dataset

From: Discovery and validation of immune-associated long non-coding RNA biomarkers associated with clinically molecular subtype and prognosis in diffuse large B cell lymphoma

Variables

Univariate analysis

Multivariate analysis

HR

95% CI of HR

P value

HR

95% CI of HR

P value

GSE31312 cohort (n = 426)

SubSigLnc-17 (ABC vs. GCB)

1.638

1.19-2.254

0.002

1.422

0.997-2.028

0.052

Age (> = 60 vs. <60)

2.01

1.41-2.864

1.12E-04

1.946

1.315-2.881

8.79E-04

Gender (Male vs. Female)

0.959

0.697-1.32

0.798

0.843

0.597-1.189

0.331

Stage (III/IV vs. I/II)

2.314

1.646-3.251

1.35E-06

1.707

1.135-2.567

0.01

LDH (High vs. Normal)

2.035

1.362-3.04

5.19 E-04

1.475

0.973-2.236

0.067

No. of extranodal sites (≥2 vs. < 2)

2.247

1.598-3.16

3.23E-06

1.778

1.213-2.605

0.003

ECOG (≥2 vs. < 2)

2.195

1.556-3.097

7.48E-06

1.584

1.065-2.355

0.023

GSE10846 cohort (n = 350)

SubSigLnc-17 (ABC vs. GCB)

2.364

1.673-3.341

1.10E-06

2.093

1.391-3.149

3.94E-04

Age (> = 60 vs. <60)

2.099

1.464-3.009

5.50E-05

1.988

1.31-3.016

0.001

Gender (Male vs. Female)

1.017

0.724-1.429

0.922

0.993

0.676-1.46

0.972

Stage (III/IV vs. I/II)

1.747

1.239-2.464

0.001

1.147

0.762-1.727

0.51

LDH (High vs. Normal)

2.643

1.791-3.899

9.72E-07

2.038

1.341-3.096

8.59E-04

No. of extranodal sites (≥2 vs. < 2)

1.899

1.087-3.317

0.024

1.183

0.58-2.415

0.644

ECOG (≥2 vs. < 2)

2.968

2.091-4.214

1.19E-09

1.907

1.246-2.918

0.003

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Molecular Cancer

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