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Fig. 2 | Molecular Cancer

Fig. 2

From: MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis

Fig. 2

miR-141 enhances ovarian cancer cell survival. QPCR analyses showed the expressions of miR-141 in, (a) (left) miR-141-overexpressing clones of A2780cp, OVCA433 and SKOV3; (right) and anti-miR141 treated cell lines; OVCA433 and SKOV3. VC: empty control and SC: scrambled control. b (left) XTT cell proliferation demonstrated that overexpression of miR-141 could remarkably enhanced the cell proliferation in A2780cp, OVCA433 and SKOV3 cell lines; (right) while inhibition of miR-141 significantly attenuated the cell proliferation in OVCA433 and SKOV3 cells with treatment of anti-miR141. The foci formation assay demonstrated that, (c) (left) overexpression of miR-141 could increase the cell viability in low-serum medium (0.1% FBS) compared with the vector control, (right) while depletion of miR-141 led to a reduction of cell viability

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