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Fig. 2 | Molecular Cancer

Fig. 2

From: MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours

Fig. 2

The mechanisms by which alteration of normal miRNA profiles can occur, leading to aberrant miRNA profiles in childhood solid tumours. Examples of aberrant expression and disrupted miRNA biogenesis are illustrated and are supported by validation in the literature. a Disruptions to miRNA genes, resulting in upregulation of oncogenic miRNAs or downregulation, or complete loss of expression (tumour suppressor miRNAs). b Components of the miRNA biogenesis pathway that can be altered, affecting production of mature functioning miRNAs. c Events which alter the target mRNA and affect the ability of the mature miRNA to bind

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Molecular Cancer

ISSN: 1476-4598