Fig. 3

High miR-4775 expression is positively correlated with EMT and Smad7/TGFβ pathway activation in CRC patients. a–b Representative IHC staining analyses of E-cadherin, N-cadherin, and vimentin in CRC tumor tissues with low or high miR-4775 expression (c–e). Spearman’s correlation analyses showed that miR-4775 was negatively associated with E-cadherin expression but positively correlated with N-cadherin and vimentin expression in 544 CRC tumor tissues (p < 0.001 for all). f–g Representative IHC staining of Smad7, p-Smad2 and p-Smad3 in pathologic serial sections of CRC tumor tissues with low and high miR-4775 expression. h–j Spearman’s correlation analyses among miR-4775, Smad7, p-Smad2 and p-Smad3 H-scores in 544 CRC tumor tissues